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Timing Of Nutrition In emergenCy laparotomy

The TONIC study

A randomised trial comparing early parenteral nutrition vs standard nutritional care following emergency laparotomy.

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Background

Emergency laparotomy refers to major surgery to treat intra-abdominal pathology such as intestinal obstruction, perforation, and infection.

This is performed for around 21,000 people each year in England and Wales. It is associated with complication rates of up to 47%, & a 90 day mortality rate of 9.6%. Outcomes have not improved from these levels over several years. Malnutrition is a key driver of poor outcomes in surgery, affecting >30% of patients admitted. Following surgery, patients may have gastrointestinal dysfunction and be unable to eat or drink, meaning nutrition must be delivered through a parenteral route. Management of nutrition is highly variable in the emergency setting.

No high quality definitive randomised trial has assessed the impact of early nutrition in a purely emergency general surgery population.

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About the Study

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